|
KMID : 0363219940320010167
|
|
Korean Journal of Dermatology
1994 Volume.32 No. 1 p.167 ~ p.171
|
|
|
A Case of Histoid Leproma with Mycobacterium Leprae Detected in the Peripheral Blood by Polymerase Chain reaction
|
|
|
|
|
Abstract
|
|
|
Histoid leproma usually occur in patients with lepromatous leprosy who have had relapsed after being under treatment(usually sulfones) for a long time and who have shown variable improvement.
A 56 year old female patient who had been suffering from lepromatous leprosy and had been treated with dapsone relatively regularly for approximately 28 years had a history of several shiny shiny rice grain to peanut sized nodules on the face and
right
flank.
Histopathologic examination of a specimen taken from a nodular lesion revealed a well circumscribed nodule composed mainly of spindle-shaed cells and epithelioid cells on the upper and middermis, and granuloma composed of epithelioid cells,
multinucleated giant cells and foamy histiocytes on the lower dermis. In AFB stain, numerous acid-fast bacilli were scattered dermis and epidermis, especially stratum corneum.
This study applied a polymerase chain reaction (PCR) on sections of biopsy tissues and peripheral blood of patient. Positive amplification of a 530 bp fragment was detected not only in the lesion tissues but also in the peripheral blood. (Kor J
Dermatol
1994 ; 32 (1) : 167~171)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|